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Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation

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Spatial characterization of electric potentials generated by pulsed microelectrode arrays.

V Kandagor¹, C J Cela, C A Sanders

¹Department of Materials Science and Engineering, University of Tennessee, Knoxville, TN 37996, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|November 25, 2010

Summary

Researchers characterized microelectrodes for retinal prosthetics, mimicking the Argus II implant. They mapped electrical potentials and surface contours to understand stimulation effects for improved visual restoration devices.

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Area of Science:

Biomedical Engineering
Neuroscience
Ophthalmology

Background:

Multielectrode retinal prosthetics aim to restore vision by stimulating remaining retinal neurons.
Accurate characterization of microelectrode stimulation is crucial for optimizing device performance and patient outcomes.
The Argus II Retinal Implant serves as a benchmark for current retinal prosthetic technology.

Purpose of the Study:

To perform in situ characterization of stimulating microelectrodes used in retinal prosthetic implants.
To replicate the geometric and electrical properties of the Argus II Retinal Implant's electrode system.
To generate topographic maps of electric potentials and surface contours during microelectrode stimulation.

Main Methods:

Utilized an experimental system that approximates the Argus II Retinal Implant's parameters.
Stimulated selected electrodes within a 60-electrode structure using biphasic, repetitively pulsed charge densities (100 microC·cm(-2)).
Created surface contour maps using a 10 micrometer diameter recording electrode to analyze electric potential topography.

Main Results:

Generated detailed topographic maps illustrating electric potential distribution around stimulated microelectrodes.
Provided surface contour maps that reveal the spatial characteristics of the electrical fields.
Quantified the electrical response of the microelectrode array under specific stimulation conditions.

Conclusions:

The study successfully characterized microelectrode stimulation in a system mimicking the Argus II implant.
The generated maps offer valuable insights into the electrical behavior of retinal prosthetic electrodes.
This characterization is essential for the design and refinement of future multielectrode retinal prosthetics for vision restoration.