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Updated: Jun 6, 2026

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response
Published on: August 10, 2017
The Rag4 glucose sensor is involved in the hypoxic induction of KlPDC1 gene expression in the yeast Kluyveromyces
C Micolonghi1, M Wésolowski-Louvel, M M Bianchi
1Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, 00185 Rome, Italy.
Abstract:
Kluyveromyces lactis is a yeast which cannot grow under strict anaerobiosis. To date, no factors responsible for oxygen sensing and oxygen-dependent regulation of metabolism have been identified. In this paper we present the identification of the glucose sensor Rag4 as a factor essential for oxygen-dependent regulation of the fermentative pathway.
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