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Related Concept Videos

Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Related Experiment Video

Updated: Jun 6, 2026

Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

Lost in (knowledge) translation!

Daren K Heyland1, Naomi E Cahill, Rupinder Dhaliwal

  • 1Department of Community Health and Epidemiology, Queen's University, Kingston, Ontario, Canada. dkh2@queensu.ca

JPEN. Journal of Parenteral and Enteral Nutrition
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Critical care nutrition guidelines show gaps between recommendations and bedside practice. Applying the knowledge-to-action model can improve nutrition therapy for critically ill patients.

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Xenopus laevis as a Model to Identify Translation Impairment
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Area of Science:

  • Critical Care Medicine
  • Nutrition Science
  • Healthcare Policy

Background:

  • Evidence-based critical care nutrition guidelines exist to guide feeding practices for critically ill patients.
  • Significant discrepancies persist between published guideline recommendations and actual clinical practice at the bedside.
  • This gap leads to suboptimal nutrition therapy for a considerable number of critically ill individuals.

Purpose of the Study:

  • To analyze the challenges in implementing critical care nutrition guidelines.
  • To apply Graham et al.'s knowledge-to-action model to the field of critical care nutrition.
  • To provide a framework for improving the translation of evidence into practice for nutrition therapy.

Main Methods:

  • Utilizing Graham et al.'s knowledge-to-action model, which comprises knowledge creation and action components.
  • Examining the 8 phases of the action cycle within the model, focusing on practical implementation strategies.
  • Illustrating model components with empirical research, commentaries, and published studies in critical care nutrition.

Main Results:

  • The knowledge-to-action model provides a structured approach to understand and address barriers in guideline implementation.
  • Specific phases of the action cycle highlight critical steps for moving research findings into clinical practice.
  • Empirical evidence demonstrates the complexities and potential solutions for knowledge translation in this specialized field.

Conclusions:

  • Understanding knowledge translation is crucial for enhancing critical care nutrition practices.
  • The knowledge-to-action model offers valuable insights for practitioners to bridge the gap between guidelines and bedside care.
  • This work aims to guide critical care nutrition professionals toward more effective and evidence-based nutrition therapy, improving patient outcomes.