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Oral ofloxacin as treatment of malignant external otitis: a study of 17 cases

R Levy1, T Shpitzer, J Shvero

  • 1Department of Otolaryngology-Head and Neck Surgery, Beilinson Medical Center, Petah Tiqva, Israel.

The Laryngoscope
|May 1, 1990
PubMed

Insights

Oral ofloxacin effectively treats malignant external otitis caused by Pseudomonas aeruginosa. This study shows significant improvement and resolution in most patients, with a low recurrence rate for this serious ear infection.

Area of Science:

  • Infectious Diseases
  • Otolaryngology
  • Pharmacology

Background:

  • Malignant external otitis is a severe infection of the ear canal.
  • Pseudomonas aeruginosa is a common pathogen in malignant external otitis.
  • Effective treatment options are crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of oral ofloxacin in treating malignant external otitis.
  • To assess the outcomes in patients with Pseudomonas aeruginosa infections.

Main Methods:

  • Seventeen patients with malignant external otitis were treated with oral ofloxacin (200 mg b.i.d.).
  • All isolates of Pseudomonas aeruginosa were sensitive to ofloxacin.
  • Treatment duration ranged from 12 to 39 days.

Main Results:

  • All patients showed subjective and objective improvement during treatment.
  • Complete resolution was achieved in all but one patient.
  • Only one patient experienced a recurrence after treatment completion.

Conclusions:

  • Oral ofloxacin is an effective treatment for malignant external otitis caused by Pseudomonas aeruginosa.
  • The drug demonstrates a favorable efficacy profile with a low recurrence rate.

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