Correlation of diffusion and perfusion MRI with Ki-67 in high-grade meningiomas
Daniel T Ginat1, Rajiv Mangla, Gabrielle Yeaney
1Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY 14620, USA. ginatd01@gmail.com
Objective:
Atypical and anaplastic meningiomas have a greater likelihood of recurrence than benign meningiomas. The risk for recurrence is often estimated using the Ki-67 labeling index. The purpose of this study was to determine the correlation between Ki-67 and regional cerebral blood volume (rCBV) and between Ki-67 and apparent diffusion coefficient (ADC) in atypical and anaplastic meningiomas.
Materials And Methods:
A retrospective review of the advanced imaging and immunohistochemical characteristics of atypical and anaplastic meningiomas was performed. The relative minimum ADC, relative maximum rCBV, and specimen Ki-67 index were measured. Pearson's correlation was used to compare these parameters.
Results:
There were 23 cases with available ADC maps and 20 cases with available rCBV maps. The average Ki-67 among the cases with ADC maps and rCBV maps was 17.6% (range, 5-38%) and 16.7% (range, 3-38%), respectively. The mean minimum ADC ratio was 0.91 (SD, 0.26) and the mean maximum rCBV ratio was 22.5 (SD, 7.9). There was a significant positive correlation between maximum rCBV and Ki-67 (Pearson's correlation, 0.69; p = 0.00038). However, there was no significant correlation between minimum ADC and Ki-67 (Pearson's correlation, -0.051; p = 0.70).
Conclusion:
Maximum rCBV correlated significantly with Ki-67 in high-grade meningiomas.
Insights
High-grade meningiomas show a significant correlation between maximum regional cerebral blood volume (rCBV) and Ki-67 index. Apparent diffusion coefficient (ADC) did not correlate with Ki-67 in these aggressive tumors.
Area of Science:
- Neuro-oncology
- Radiology
- Pathology
Background:
- Atypical and anaplastic meningiomas recur more frequently than benign types.
- The Ki-67 labeling index is a key prognostic marker for meningioma recurrence.
- Advanced imaging techniques may offer non-invasive methods to assess tumor aggressiveness.
Purpose of the Study:
- To investigate the correlation between Ki-67 labeling index and advanced imaging parameters in atypical and anaplastic meningiomas.
- To determine if regional cerebral blood volume (rCBV) or apparent diffusion coefficient (ADC) can predict Ki-67 levels.
- To assess the utility of MRI-based biomarkers for grading high-grade meningiomas.
Main Methods:
- Retrospective analysis of 23 atypical and anaplastic meningiomas.
- Measurement of relative minimum ADC and relative maximum rCBV from advanced imaging.
- Correlation analysis between imaging parameters (ADC, rCBV) and Ki-67 index using Pearson's correlation.
Main Results:
- A significant positive correlation was found between maximum rCBV and Ki-67 index (r=0.69, p=0.00038).
- No significant correlation was observed between minimum ADC and Ki-67 index (r=-0.051, p=0.70).
- The average Ki-67 index was 17.6% in cases with ADC maps and 16.7% with rCBV maps.
Conclusions:
- Maximum rCBV is a significant imaging biomarker correlating with Ki-67 in high-grade meningiomas.
- ADC measurements do not appear to correlate with tumor proliferation in these aggressive meningiomas.
- rCBV shows potential as a non-invasive predictor of meningioma aggressiveness.
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