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Probable interaction between warfarin and bee pollen.

Kathryn M Hurren¹, Carrie L Lewis

¹Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA. k.hurren@wayne.edu

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|November 25, 2010

Summary

This summary is machine-generated.

A patient taking warfarin experienced elevated International Normalized Ratio (INR) levels after consuming bee pollen. This probable interaction highlights the need for caution when combining warfarin with herbal supplements like bee pollen.

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Area of Science:

Pharmacology
Herbal Medicine Interactions

Background:

Warfarin is a common anticoagulant medication used to prevent blood clots.
Patients often use herbal products and supplements for perceived health benefits.
Potential interactions between warfarin and herbal products require careful monitoring.

Observation:

A patient on stable warfarin therapy developed a significantly elevated International Normalized Ratio (INR) of 7.1.
The elevated INR occurred after the patient began a regimen of bee pollen granules.
No other changes in medication, diet, or health status were reported by the patient.

Findings:

Warfarin dosage adjustment was necessary after withholding the medication temporarily.
The patient's INR normalized after warfarin was restarted at a reduced dose while continuing bee pollen.
A probable interaction between bee pollen and warfarin was indicated by the Drug Interaction Probability Scale.

Implications:

Bee pollen consumption may increase the anticoagulant effect of warfarin.
Healthcare providers should inquire about herbal supplement use in patients on warfarin.
Further research is warranted to elucidate the mechanism of this herb-drug interaction.