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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Prediction of chronic renal insufficiency after coronary angiography by an early increase in oxidative stress and
Kazuko Tajiri1, Hidekazu Maruyama, Akira Sato
1Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Summary
Oxidative stress markers and early kidney function decline after contrast angiography predict long-term renal insufficiency. Early detection and intervention are crucial for patients undergoing these procedures.
Area of Science:
- Nephrology
- Cardiology
- Biomarkers
Background:
- Contrast media administration is linked to contrast-induced acute kidney injury.
- Oxidative stress is a key mechanism in contrast-induced nephrotoxicity.
- Long-term renal function implications require further investigation.
Purpose of the Study:
- To assess the relationship between contrast agent-induced oxidative stress and long-term renal function.
- To identify early indicators of chronic kidney injury post-coronary angiography.
Main Methods:
- Prospective study enrolling 36 patients undergoing coronary angiography.
- Measurement of urinary F2-isoprostane (oxidative stress marker) at baseline and 24 hours post-procedure.
- Assessment of serum creatinine and estimated glomerular filtration rate (eGFR) at baseline, 24 hours, and 1 year.
Main Results:
- A significant correlation was found between the change in eGFR at 24 hours and at 1 year post-angiography (r=0.729, P<0.001).
- Increased urinary F2-isoprostane at 24 hours correlated with decreased eGFR at 1 year (r=0.439, P=0.022).
- Multivariate analysis confirmed that increased F2-isoprostane and decreased eGFR at 24 hours predicted decreased eGFR at 1 year.
Conclusions:
- Contrast-induced nephrotoxicity may be transient, but early changes indicate potential chronic issues.
- Early eGFR decrease and elevated oxidative stress are associated with long-term renal insufficiency.
- Patients require long-term monitoring and medical intervention to manage risks.
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