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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Older age and greater carotid intima-media thickness predict ischemic events associated with carotid-artery stenting

Michael Rosenkranz1, Götz Thomalla, Stefanie Havemeister

  • 1Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. rosenkranz@uke.de

Cerebrovascular Diseases (Basel, Switzerland)
|November 25, 2010
PubMed

Insights

Older age and increased carotid intima-media thickness (IMT) predict stroke risk after carotid-artery stenting (CAS). Patients with both factors face the highest risk of procedure-related ischemic events.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Carotid-artery stenting (CAS) is a procedure to treat carotid stenosis but carries a risk of stroke.
  • Identifying predictors of these procedure-related ischemic events is crucial for patient safety.

Purpose of the Study:

  • To determine predictors of new ischemic lesions in diffusion-weighted MRI (DWI) after CAS.
  • To identify patient characteristics associated with an increased risk of stroke post-CAS.

Main Methods:

  • Diffusion-weighted MRI (DWI) was used to analyze new ischemic lesions in 147 patients undergoing CAS.
  • Nine covariates, including age, hypertension, diabetes, dyslipidemia, smoking, stenosis severity, intervention side, and carotid intima-media thickness (IMT), were assessed.

Main Results:

  • Age and IMT were independently associated with new DWI lesions.
  • An age of 68 years and an IMT of 1.5 mm best stratified risk.
  • Patients aged ≥68 years with IMT >1.5 mm had the highest risk (69.6%) of new DWI lesions.

Conclusions:

  • Older age and greater IMT are significant independent predictors of CAS-related ischemic events.
  • The combination of older age and greater IMT substantially increases the risk of stroke after CAS.
Abstract

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