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Updated: Jun 6, 2026

Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices
Published on: April 13, 2021
Adding efficiency: the role of the CAN ion channels TRPM4 and TRPM5 in pancreatic islets
Thorsten Enklaar1, Lili R Brixel, Bernhard U Zabel
1Centre for Paediatrics and Adolescent Medicine, University Medical Centre of the Johannes Guetenberg-University, Mainz, Germany.
Abstract:
Insulin secretion in β-pancreatic cells after glucose stimulation requires the concerted action of a number of different ion channels. The main players seem to be the ATP sensitive K(+) (KATP-) channels, and voltage gated ion channels that drive Ca(2+) influx into β-cells. Recently two calcium activated nonselective (CAN) cation channels (TRPM4 and TRPM5) have been shown to influence efficient insulin response upon glucose stimulation. This addendum summarizes the data known for these two TRP channels in β-cells, discusses some of the remaining open questions and addresses a possible scenario that involves and integrates the triggering and amplifying pathway of glucose mediated insulin secretion.
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