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Published on: August 21, 2021
A case report of doxycycline-induced Stevens-Johnson syndrome
Brian Lau1, Divya Mutyala, Deepinder Dhaliwal
1University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Purpose:
To report the clinical findings of a case of Stevens-Johnson syndrome (SJS) precipitated by the use of systemic doxycycline.
Methods:
Case report.
Results:
A 49-year-old man developed SJS with ocular involvement after doxycycline use for respiratory symptoms. The patient developed persistent 2+ conjunctival injection and foreshortening of the conjunctival fornices in both eyes. The right eye had a 3 × 3.4 mm corneal epithelial defect with 50% thinning. The left eye had a 2.6 × 3 mm corneal ulcer with a central perforation and a flat anterior chamber with 360 degrees of iridocorneal touch.
Conclusions:
This case illustrates the unusual presentation of SJS induced by doxycycline. The prevalent use of systemic doxycycline in the practice of ophthalmology for eyelid-related and ocular surface disorders coupled with the detrimental long-term sequelae of SJS renders a careful reevaluation for alternatives.
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