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Gastrin, motilin and pancreatic polypeptide levels after two different parenteral regimens in infants
J Ksiazyk1, T L Peeters, J Socha
1Department of Gastroenterology, Child Health Center, Warsaw, Poland.
Insights
Parenteral nutrition regimens in infants did not significantly alter gastrin, motilin, or pancreatic polypeptide (PP) levels. Lipid addition to parenteral nutrition also showed no impact on these peptide levels.
Area of Science:
- Pediatric Gastroenterology
- Endocrinology
- Nutritional Science
Background:
- Parenteral nutrition is crucial for infants unable to receive enteral feeding.
- Hormonal regulation of digestion, including peptide levels, is vital in infant development.
- Understanding peptide responses to parenteral nutrition is important for optimizing infant care.
Purpose of the Study:
- To investigate the impact of two different parenteral nutrition regimens on infant peptide levels.
- To determine if lipid content in parenteral nutrition affects gastrin, motilin, and pancreatic polypeptide (PP) levels.
- To assess the stability of these peptide levels during parenteral feeding.
Main Methods:
- Radioimmunoassay was used to measure plasma peptide levels in 15 infants (aged 1-25 months).
- Measurements were taken in a fasting state and after a 2-hour infusion of two different parenteral regimens.
- Regimen A included amino acids, glucose, and lipids; Regimen B included amino acids and glucose only.
Main Results:
- Infant peptide levels (gastrin, motilin, PP) showed minimal and non-significant changes between pre- and post-infusion.
- The addition of lipids to parenteral nutrition did not influence gastrin, motilin, or PP levels.
- Basal peptide levels remained stable throughout the observation period, indicating unaffected regulatory mechanisms.
Conclusions:
- Parenteral nutrition regimens, with or without lipids, do not significantly alter circulating levels of gastrin, motilin, and pancreatic polypeptide in infants.
- The regulatory mechanisms for basal secretion of these peptides appear unaffected by short-term parenteral feeding.
- These findings suggest a stable hormonal environment regarding these peptides during standard parenteral nutrition in infants.
Abstract:
We studied the effect of 2 different parenteral regimens upon gastrin, motilin and pancreatic polypeptide (PP) levels in infants. In 15 children, aged 1-25 months, plasma peptide levels were measured by radioimmunoassay in the fasting state and after a 2-h infusion of either a mixture of amino acids, glucose and lipids (A) or a mixture of amino acids and glucose (B) only. Wide interindividual fluctuations were noted, especially for motilin and PP, but, except for PP, intraindividual fluctuations were low. Indeed, a good correlation was found, not only between the 2 pre-infusion levels, but also between pre- and postinfusion levels in both experiments. In fact for all 3 peptides, pre- and postinfusion levels differed only slightly and non-significantly. We conclude that during parenteral feeding levels of motilin, PP and gastrin remain practically unchanged and are not influenced by the addition of lipids. In addition, during the observation period basal levels did not change, indicating that the mechanisms regulating basal secretion were not affected.