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Maternal effect on micronucleus induction in MS/Ae mice.

S Sutou1, S Sato

  • 1Itoham Central Research Institute, Ibaraki, Japan.

Environmental and Molecular Mutagenesis
|January 1, 1990
PubMed
Summary
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Maternal factors in MS/Ae mice influence mutagen sensitivity and offspring development. These mutagen-sensitive mice showed lower incidences of micronucleated cells and reduced body weight when offspring were maternally derived from MS/Ae dams.

Area of Science:

  • Genetics
  • Toxicology
  • Developmental Biology

Background:

  • MS/Ae mice exhibit mutagen sensitivity in dominant lethal and micronucleus tests.
  • CD-1 mice are the parental strain for MS/Ae mice.
  • Understanding genetic and maternal influences on mutagen sensitivity is crucial.

Purpose of the Study:

  • To investigate the influence of maternal versus paternal factors on mutagen sensitivity in MS/Ae mice.
  • To assess differential responses to mutagens in offspring from reciprocal crosses.

Main Methods:

  • Reciprocal crosses between MS/Ae and CD-1 mice.
  • Micronucleus test on male and female offspring using mitomycin C (MMC), colchicine (Col), and 6-mercaptopurine (6-MP).
  • Evaluation of micronucleated polychromatic erythrocyte incidence and offspring body weight.

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Main Results:

  • Mitomycin C and 6-mercaptopurine showed differential responses.
  • Offspring from CD-1 dams had lower micronucleated cell incidences than those from MS/Ae dams.
  • Offspring from MS/Ae dams exhibited lower body weights and tended to have smaller litter sizes.

Conclusions:

  • Mutagen sensitivity traits in MS/Ae mice are predominantly associated with maternal factors.
  • Maternal genetic or environmental influences play a significant role in offspring mutagen response and development.
  • Further research is needed to elucidate specific maternal mechanisms involved.