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Related Experiment Video

Updated: Jun 6, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Infectious keratitis treated with corneal crosslinking.

Karim Makdoumi¹, Jes Mortensen, Sven Crafoord

¹Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden. karim.makdoumi@orebroll.se

|November 25, 2010

Summary

Collagen crosslinking (CXL) with riboflavin effectively treated severe infectious keratitis, halting corneal melting and promoting healing. This innovative approach shows promise for challenging microbial keratitis cases.

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Area of Science:

Ophthalmology
Microbiology
Biomedical Engineering

Background:

Severe infectious keratitis poses a significant threat to vision.
Standard treatments may be insufficient for aggressive microbial keratitis.
Corneal melting necessitates urgent and effective therapeutic interventions.

Observation:

Seven eyes with severe infectious keratitis, including cases with corneal melting, were treated with collagen crosslinking (CXL).
Patients experienced symptom improvement within 24 hours, with arrested corneal melting and complete epithelialization in all cases.
Hypopyon regressed completely within 48 hours in eyes where it was present.

Findings:

Collagen crosslinking (CXL) demonstrated rapid and positive clinical outcomes in severe infectious keratitis.
The treatment effectively halted corneal melting and facilitated tissue repair.
Symptomatic relief and visual improvement were observed shortly after CXL application.

Implications:

CXL represents a potentially valuable therapeutic option for managing severe infectious keratitis.
Further research is warranted to fully establish the efficacy and long-term benefits of CXL in infectious keratitis.
This study highlights the potential of CXL as an adjunct or alternative treatment in challenging ophthalmic infections.