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Gastrointestinal Motility Monitor (GIMM)

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

Transmembrane guanylate cyclase in intestinal pathophysiology.

Kris A Steinbrecher¹, Mitchell B Cohen

¹Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Current Opinion in Gastroenterology

|November 25, 2010

Summary

Guanylate cyclase (GC) and cyclic guanosine monophosphate (cGMP) are crucial for intestinal function. Recent research highlights their role in secretory disorders, motility, and cancer, paving the way for new therapies.

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In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability

Published on: October 19, 2018

Area of Science:

Gastroenterology
Molecular Biology
Pharmacology

Background:

Guanylate cyclase (GC) produces cyclic guanosine monophosphate (cGMP), essential for gastrointestinal physiology.
Maintaining cGMP homeostasis is vital for intestinal secretion, cell proliferation, and apoptosis.

Purpose of the Study:

Review recent findings on transmembrane guanylate cyclases in intestinal disorders.
Explore therapeutic potential of manipulating GC/cGMP signaling for constipation and GI cancer.

Main Methods:

Review of in-vitro studies and gene-targeted animal models.
Analysis of ongoing clinical trials for GC-activating peptides.

Main Results:

Transmembrane GCs influence intestinal fluid secretion and enteric-renal signaling.
GC-activating peptides show safety and efficacy for constipation and IBS.
GC signaling regulates intestinal epithelial cell homeostasis and impacts GI malignancy.

Conclusions:

Advances in understanding GC/cGMP physiology have led to new therapeutic agents.
Further research needed on cGMP effector pathways and their role in intestinal health and disease.