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Right ventricular function in children with severe respiratory syncytial virus (RSV) bronchiolitis

K Thorburn1, M Eisenhut, A Shauq

  • 1Department of Pediatric Intensive Care, Royal Liverpool Children's Hospital - Alder Hey, Liverpool, UK. kent.thorburn@alderhey.nhs.uk

Minerva Anestesiologica
|November 25, 2010
PubMed

Insights

Severe respiratory syncytial virus (RSV) infection in children can cause reduced right ventricular function. This dysfunction was observed but not linked to myocardial or liver damage in a pediatric intensive care unit study.

Area of Science:

  • Pediatric Cardiology
  • Pediatric Critical Care Medicine
  • Infectious Diseases

Background:

  • Severe respiratory syncytial virus (RSV) infection in children is linked to myocardial damage and hepatitis.
  • Understanding the impact on cardiac function is crucial for managing severe pediatric illness.

Purpose of the Study:

  • To assess right ventricular (RV) function in children with severe RSV disease.
  • To investigate the association between RV function and disease severity, myocardial damage, and hepatitis.

Main Methods:

  • Prospective observational study in a pediatric intensive care unit (PICU).
  • Echocardiographic assessment of RV function (Tei index) and left ventricular function.
  • Measurement of cardiac troponin T, transaminases, and C-reactive protein levels.

Main Results:

  • Twenty percent of ventilated children with severe RSV infection showed reduced RV function (elevated Tei index).
  • No significant difference in left ventricular function, C-reactive protein, or transaminase levels based on RV function.
  • Elevated cardiac troponin T occurred in 41% of patients, not significantly associated with RV function.

Conclusions:

  • Reduced right ventricular function is present in severe RSV disease.
  • The degree of RV dysfunction was not correlated with biochemical markers of myocardial/hepatic damage or respiratory support needs.
Abstract

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