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Related Concept Videos

Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Drug Absorption: Factors Affecting GI Absorption01:19

Drug Absorption: Factors Affecting GI Absorption

The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
In...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

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Related Experiment Video

Updated: Jun 6, 2026

A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating
09:01

A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating

Published on: July 8, 2016

Substrate effects on absorption of coated surfaces.

P Roche, M Commandré, L Escoubas

    Applied Optics
    |November 25, 2010
    PubMed
    Summary

    Photothermal deflection accurately maps surface absorption. Substrate properties significantly impact coated component losses, especially near surfaces and interfaces.

    Area of Science:

    • Materials Science
    • Optical Engineering
    • Surface Science

    Background:

    • Optical coatings are crucial for component performance.
    • Substrate properties can significantly influence total optical losses.
    • Understanding absorption at interfaces and surfaces is key.

    Purpose of the Study:

    • To map surface absorption of bare and coated substrates using photothermal deflection.
    • To investigate the influence of substrate type and surface contamination on coated component absorption.
    • To analyze absorption localization in coated films.

    Main Methods:

    • Photothermal deflection technique for absorption mapping.
    • Comparative analysis of BK7 and fused-silica substrates.
    • In-situ mapping before and after coating, and post-annealing.

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    Preparation of Nanoparticles for ToF-SIMS and XPS Analysis

    Published on: September 13, 2020

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    Last Updated: Jun 6, 2026

    A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating
    09:01

    A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating

    Published on: July 8, 2016

    Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
    08:50

    Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

    Published on: September 26, 2014

    Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
    06:24

    Preparation of Nanoparticles for ToF-SIMS and XPS Analysis

    Published on: September 13, 2020

    Main Results:

    • Substrate type strongly affects coated-substrate absorptance.
    • Surface contamination of bare substrates impacts total absorption.
    • Absorption is localized at the substrate's near-surface and film interfaces.

    Conclusions:

    • Substrate selection is critical for minimizing optical losses in coated components.
    • Photothermal deflection is effective for diagnosing absorption in optical coatings.
    • Interface and near-surface absorption are primary contributors to optical losses.