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Synthetic Utility of Epoxides for Chiral Functionalization of Isoxazoles

Jared K Nelson1, Christopher T Burns, Miles P Smith

  • 1Department of Chemistry, University of Idaho, Moscow, ID 83844-2343.

Tetrahedron Letters
|November 25, 2010
PubMed

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Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...
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