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Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report
L F F Botelho1, F R Picosse, M H Padilha
1Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil.
Case Reports in Dermatology
|November 25, 2010
Summary
A rare skin condition, acute generalized exanthematous pustulosis (AGEP), can be triggered by antibiotics like cefepime. Promptly identifying and stopping the causative drug leads to rapid symptom resolution.
Area of Science:
- Dermatology
- Pharmacology
- Internal Medicine
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a rare, severe skin reaction.
- It presents as widespread sterile pustules and is often drug-induced.
Observation:
- A 67-year-old male developed AGEP after initiating cefepime for pneumonia.
- The patient presented with a pruritic rash and disseminated pustular lesions.
- Skin biopsy confirmed subcorneal pustules and neutrophilic infiltrate.
Findings:
- Cefepime, a fourth-generation cephalosporin, was identified as the likely cause of AGEP.
- Discontinuation of cefepime resulted in rapid clearance of pustules and desquamation within 4 days.
Implications:
- This case highlights cephalosporins as potential, though less common, triggers for AGEP.
- Early recognition and drug withdrawal are crucial for managing antibiotic-induced AGEP.
- Investigating drug reactions is essential for patients presenting with acute pustular rashes.
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