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Published on: September 7, 2013
A comparative analysis shows morphofunctional differences between the rat and mouse melanin-concentrating hormone
Sophie Croizier1, Gabrielle Franchi-Bernard, Claude Colard
1Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon, France.
Plos One
|November 25, 2010
Summary
Sub-populations of melanin-concentrating hormone (MCH) neurons exist in mice, differing from rats in abundance and axonal distribution. These MCH system variations suggest distinct roles in feeding and sleep-wake cycles between species.
Area of Science:
- Neuroscience
- Comparative Anatomy
- Neuroendocrinology
Background:
- Melanin-concentrating hormone (MCH) neurons exhibit distinct sub-populations in rats, characterized by specific projection patterns and gene expression.
- Such detailed characterization of MCH neuron sub-populations has not been reported in other species, particularly mice.
Purpose of the Study:
- To investigate and characterize the anatomical and morphofunctional organization of the MCH system in mice.
- To compare the MCH system in mice with that of rats, given the common use of mouse models in research.
Main Methods:
- Utilized multiple immunohistochemistry techniques.
- Combined in situ hybridization, tract tracing, and BrdU injections for comprehensive analysis.
- Investigated the distribution of MCH neurons and their axonal projections.
Main Results:
- Confirmed the existence of MCH neuron sub-populations in mice, though their relative abundance differs from rats.
- Observed significant divergences in MCH axon distribution, notably within the ventromedial hypothalamus.
- Identified species-specific differences in the MCH system's organization between rats and mice.
Conclusions:
- The MCH systems in rats and mice are not identical, exhibiting notable differences in neuron sub-population distribution and axonal projections.
- These anatomical and organizational divergences suggest differential involvement of rat and mouse MCH neurons in regulating feeding and sleep-wake cycles.
