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Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...

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Related Experiment Video

Updated: Jun 6, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

The association between blood coagulation activity and lung function: a population-based study.

Andrew W Fogarty1, Sarah A Lewis, Tricia M McKeever

  • 1Respiratory Biomedical Research Unit, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, United Kingdom. andrew.fogarty@nottingham.ac.uk

Plos One
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Blood coagulation activation, measured by plasma D-dimer, is linked to reduced lung function in a cross-sectional study. Systemic inflammation may play a role, but D-dimer pathways are unlikely therapeutic targets for respiratory disease.

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Related Experiment Videos

Last Updated: Jun 6, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Epidemiology

Background:

  • Lower lung function is associated with increased susceptibility to thrombotic disease.
  • Investigating the link between blood coagulation activation and lung function is crucial for potential new interventions.
  • Plasma D-dimer levels serve as a marker for blood coagulation pathway activity.

Purpose of the Study:

  • To investigate the association between plasma D-dimer levels and lung function.
  • To explore the role of systemic inflammation in this association.
  • To determine if coagulation pathways involving D-dimer are a viable therapeutic target for respiratory diseases.

Main Methods:

  • Cross-sectional study of 2463 randomly selected adults in 1991, with follow-up of 1252 in 2000.
  • Analysis of plasma D-dimer levels from baseline 1991 samples.
  • Assessment of lung function parameters including Forced Expiratory Volume in one second (FEV1) and Forced Vital Capacity (FVC).

Main Results:

  • An inverse cross-sectional association was found between plasma D-dimer and FEV1 (decrease of 71 ml per µg FEU/ml increment).
  • Plasma D-dimer was also inversely associated with FVC (decrease of 97 ml per µg FEU/ml increase).
  • These associations were attenuated after adjusting for highly sensitive C-reactive protein (CRP), suggesting a role for systemic inflammation. No association was observed with the decline in lung function over time.

Conclusions:

  • Cross-sectional data support a hypothesis linking blood coagulation activation to decreased lung function, potentially mediated by systemic inflammation.
  • The absence of an association with lung function decline suggests that D-dimer-related clotting pathways may not be a promising therapeutic target for respiratory diseases.
  • Further research is needed to fully elucidate the complex relationship between coagulation, inflammation, and lung function.