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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...
Body Temperature01:07

Body Temperature

Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...
Body Temperature01:25

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...

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A Preclinical Model of Exertional Heat Stroke in Mice
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A Preclinical Model of Exertional Heat Stroke in Mice

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Morphological changes during acute experimental short-term hyperthermia.

M Vlad1, N Ionescu, Al Th Ispas

  • 1Department of Clinical Anatomy and Surgical Techniques, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. vlad_marius@hotmail.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Exposure to high temperatures (40.5°C) caused significant vascular damage and organ failure in Wistar rats. Key findings include widespread red blood cell extravasation and tissue damage across multiple organs.

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Last Updated: Jun 6, 2026

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Area of Science:

  • Toxicology
  • Pathology
  • Physiology

Background:

  • High temperatures pose a significant threat to physiological systems.
  • Understanding organ-specific responses to heat stress is crucial for predicting health outcomes.

Purpose of the Study:

  • To investigate the pathological effects of acute heat exposure on Wistar rat organs.
  • To identify specific vascular and tissue lesions induced by high temperatures.

Main Methods:

  • Wistar rats were exposed to 40.5°C for 30 minutes.
  • Organs (heart, lung, liver, pancreas, kidneys, adrenal gland) were harvested post-exposure.
  • Histopathological examination was performed to identify vascular and tissue changes.

Main Results:

  • Widespread vascular lesions observed, including red blood cell extravasation and vascular stasis.
  • Myocardial fibers fragmented, lungs showed hemorrhagic alveolitis, and liver exhibited granulo-vacuolar dystrophy.
  • Kidneys displayed narrowed vascular spaces and tubular changes; adrenal glands showed capillary dilatation and extravasation.

Conclusions:

  • Acute exposure to 40.5°C induces severe multi-organ vascular damage in Wistar rats.
  • Observed pathological changes suggest a pathway towards functional organ failure.
  • Heat stress significantly impacts cardiovascular and organ systems, necessitating further research into protective mechanisms.