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Related Experiment Video

Updated: Jun 6, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Soft tissue epithelioid angiosarcoma.

Codruţa Lăzureanu1, Flavia Baderca, O Burlacu

  • 1Department of Pathology, Victor Babes, University of Medicine and Pharmacy, Timisoara, Romania. dordecodru@yahoo.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|November 25, 2010
PubMed
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A rare epithelioid angiosarcoma of the soft tissue was misdiagnosed as carcinoma due to its cellular characteristics. Immunohistochemistry confirmed the diagnosis, guiding adjuvant therapy for this aggressive tumor.

Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Epithelioid angiosarcoma is a rare and aggressive soft tissue malignancy.
  • Accurate diagnosis is crucial for appropriate treatment and patient outcomes.

Observation:

  • A 48-year-old male presented with a painful paravertebral mass, dyspnea, and hemoptysis.
  • CT imaging revealed a large tumor invading local structures, including ribs and pleura.
  • Histopathological examination showed cohesive malignant cells, leading to an initial misdiagnosis of carcinoma.

Findings:

  • Immunohistochemical analysis, utilizing a panel of antibodies including pan-CK, CD34, and Ki-67, confirmed the diagnosis of epithelioid angiosarcoma.
  • High proliferative activity (30% Ki-67 positivity) indicated an aggressive tumor.

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  • The tumor exhibited lymph node metastasis.

    • Implications:

    • This case highlights the importance of comprehensive immunohistochemical evaluation in differentiating epithelioid angiosarcoma from carcinoma.
    • Adjuvant radiotherapy and chemotherapy were indicated for this aggressive tumor.
    • Despite local recurrence, the patient remained alive 22 months post-surgery, underscoring the need for continued research into effective treatment strategies.