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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 6, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Preoperative therapy: recent findings.

Takayuki Kinoshita1

  • 1Department of Breast Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. takinosh@ncc.go.jp

Breast Cancer (Tokyo, Japan)
|November 25, 2010
PubMed
Summary

Preoperative systemic therapy (PST) is effective for breast cancer, offering improved surgical options for advanced cases and disease freedom for operable cases. This approach allows for more lumpectomies and aids in studying breast cancer biology.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Preoperative systemic therapy (PST) is a standard treatment for locally advanced breast cancer.
  • PST is also a viable option for primary operable breast cancer.
  • PST demonstrates efficacy comparable to postoperative adjuvant therapy.

Purpose of the Study:

  • To summarize the current consensus on the adoption and benefits of PST.
  • To highlight the advantages of PST, particularly for operable breast cancer patients.
  • To discuss advancements in breast cancer treatment and understanding influencing PST use.

Main Methods:

  • Literature review of current consensus on PST.
  • Analysis of PST effectiveness in locally advanced and operable breast cancer.

Related Experiment Videos

Last Updated: Jun 6, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

  • Evaluation of PST's role in surgical options and disease control.

    • Main Results:

    • PST is as effective as adjuvant therapy for breast cancer.
    • PST enables more breast-conserving surgeries (lumpectomies).
    • PST facilitates the study of breast cancer biology.

    Conclusions:

    • PST improves surgical options for locally advanced breast cancer.
    • PST aims to achieve disease freedom for operable breast cancer patients.
    • The adoption and benefits of PST are evolving with treatment advances.