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A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

Feeding disorders and obesity.

Cristina Cervino¹, Valentina Vicennati, Renato Pasquali

¹Endocrinology Unit and C.R.B.A., Department of Clinical Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy.

Current Topics in Behavioral Neurosciences

|November 25, 2010

Summary

The endocannabinoid system regulates appetite and energy balance via brain and peripheral tissues. Blocking cannabinoid type 1 receptors may treat obesity and related metabolic risks.

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Area of Science:

Neuroendocrinology
Metabolic Science

Background:

The endocannabinoid (EC) system plays a crucial role in regulating appetite, food intake, and energy balance.
It influences the rewarding aspects of food through mesolimbic pathways and hypothalamic networks.
The EC system also impacts metabolic functions in peripheral tissues like adipose tissue, liver, muscle, and pancreas.

Purpose of the Study:

To explore the multifaceted roles of the EC system in appetite control and energy homeostasis.
To investigate the EC system's involvement in peripheral metabolic regulation.
To highlight the therapeutic potential of targeting the EC system for obesity and metabolic disorders.

Main Methods:

Review of existing literature on the endocannabinoid system's functions.
Analysis of the EC system's action in both central (brain) and peripheral systems.
Examination of the link between EC system overactivation and visceral obesity.

Main Results:

The EC system modulates food reward and appetite via central mechanisms.
Peripheral tissues are significantly influenced by EC system activity, affecting overall metabolism.
Visceral obesity is associated with an overactive EC system.

Conclusions:

The endocannabinoid system is a key regulator of appetite and energy balance through integrated central and peripheral actions.
Targeting cannabinoid type 1 receptors offers a promising therapeutic strategy for managing obesity and associated cardiometabolic risks.