Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Respiratory Assessment: Purpose and Indications

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

Physical Assessment of the Respiratory Tract II: Inspection

Physical Assessment of the Respiratory Tract II: Inspection

Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration can...

Assessment of Respiration

Assessment of Respiration

The respiratory system's basic structures and primary functions lay the foundation for nurses' comprehensive respiratory assessments. This assessment includes subjective and objective data to gauge the patient's respiratory health.
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like asthma or COPD,...

Microbiota of the Respiratory Tract

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...

Respiratory System Abnormal Finding II: Palpation and Auscultation

Respiratory System Abnormal Finding II: Palpation and Auscultation

In assessing respiratory abnormalities, palpation and auscultation are critical tools for detecting and interpreting various pathophysiological changes. These techniques provide insight into underlying disorders by evaluating tactile sensations and sounds produced by the respiratory system.
Palpation Findings
During a respiratory assessment, palpation can reveal several vital abnormalities:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ultrasound-guided midline catheters in the neonatal intensive care unit: a single-center pilot study.

European journal of pediatrics·2026

Same author

Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

Chest·2026

Same author

Verbal Episodic Processing in Newborns.

eLife·2026

Same author

Impact of regional heterogeneity of RSV infection prophylaxis on bronchiolitis in Italy.

Italian journal of pediatrics·2026

Same author

Long term lung health in children: new emerging threats and preventive strategies.

Paediatric respiratory reviews·2026

Same author

Protecting infants from RSV: cost-effectiveness of nirsevimab in a real-world study from Chile.

Lancet regional health. Americas·2026

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Conducting Respiratory Oscillometry in an Outpatient Setting

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

Endpoints in respiratory diseases.

Fernando Maria de Benedictis¹, Roberto Guidi, Silvia Carraro

¹Department of Pediatrics, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy.

European Journal of Clinical Pharmacology

|November 25, 2010

Summary

This summary is machine-generated.

Standardizing outcome measures in pediatric respiratory clinical trials is crucial for comparing treatments and assessing patient benefit. This review discusses common endpoints for acute and chronic childhood respiratory conditions.

More Related Videos

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

Related Experiment Videos

Last Updated: Jun 6, 2026

Conducting Respiratory Oscillometry in an Outpatient Setting

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

Area of Science:

Pediatric Pulmonology
Clinical Trial Methodology
Respiratory Medicine

Background:

Diverse outcome measures in pediatric respiratory trials hinder treatment comparison and evaluation of clinical benefit.
Current trials utilize subjective, objective, and health-related endpoints, with varying degrees of accuracy, precision, and reliability.
Distinguishing between clinical and surrogate endpoints is vital, requiring clear definition of their association for meaningful interpretation.

Purpose of the Study:

To review common endpoints used in clinical trials for pediatric respiratory diseases.
To highlight challenges in comparing treatment outcomes due to endpoint variability.
To emphasize the need for accurate, precise, and reliable endpoints in pediatric respiratory research.

Main Methods:

Review of common endpoints in published pediatric respiratory clinical trials.
Categorization of diseases into acute (bronchiolitis, viral-wheeze, asthma, croup) and chronic (asthma, cystic fibrosis) for practical analysis.
Discussion of the characteristics of an ideal clinical trial endpoint.

Main Results:

A wide array of outcome measures are employed, complicating cross-trial comparisons.
Endpoints are broadly classified into subjective, objective, and health-related categories.
Common endpoints for acute conditions like bronchiolitis and chronic conditions like cystic fibrosis are examined.

Conclusions:

Standardization of endpoints is essential for robust clinical trial data in pediatric respiratory medicine.
Further endpoint development is needed to improve the prognosis and safety of treatments for children.
Clearer definitions and validation of surrogate endpoints are necessary for their effective use.