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[Arterial hypertension and metabolic disorders]

I S Dzherieva, N I Volkova

    Klinicheskaia Meditsina
    |November 26, 2010
    PubMed

    Insights

    Arterial hypertension and metabolic disorders accelerate organ damage, with metabolic severity impacting myocardial hypertrophy and arterial stiffness. These conditions, alongside psychic issues, may link to disrupted circadian rhythms and abnormal melatonin secretion.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Psychiatry

    Background:

    • Arterial hypertension (AH) and metabolic disorders accelerate target organ damage.
    • Myocardial hypertrophy rate correlates with metabolic disturbance severity.
    • Arterial rigidity is an independent risk factor for cardiovascular complications in obesity.

    Purpose of the Study:

    • To investigate the relationship between arterial hypertension, metabolic disorders, and their impact on target organs.
    • To explore the connection between metabolic syndrome components and kidney function.
    • To examine the role of circadian rhythm disruption and melatonin secretion in patients with combined AH, metabolic, and psychic disorders.

    Main Methods:

    • Prospective studies analyzing myocardial hypertrophy and metabolic disturbance severity.
    • Correlation analysis between left atrial enlargement, fasting glycemia, and body mass.
    • Assessment of microalbuminurea, hyperinsulinemia, and glomerular filtration rate.
    • Evaluation of arterial rigidity as a risk factor in obese patients.
    • Investigation of affective disorders and their impact on quality of life and therapy motivation.
    • Consideration of abnormal melatonin secretion and disturbed circadian rhythms.

    Main Results:

    • Myocardial hypertrophy rate closely correlates with metabolic disturbance severity.
    • Left atrial enlargement correlates with fasting glycemia and excess body mass.
    • Microalbuminurea is closely related to hyperinsulinemia.
    • Increased number of metabolic syndrome components linearly correlates with reduced glomerular filtration rate (<60 ml/min).
    • Arterial rigidity is a new independent risk factor for cardiovascular complications in obese patients.
    • Metabolic disturbances contribute to affective disorders, reducing quality of life and therapy motivation.

    Conclusions:

    • The combination of AH and metabolic disorders significantly accelerates organic lesions.
    • Metabolic syndrome components are linked to impaired kidney function and increased cardiovascular risk.
    • Disrupted circadian rhythms and abnormal melatonin secretion may be consequences of combined AH, metabolic, and psychic disorders, impacting overall health and treatment adherence.

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