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Lymph node biopsies: a hospital based retrospective study.

A K Shrestha1, P R Chalise, M L Shrestha

  • 1The Royal Marsden Hospital, London, UK.

JNMA; Journal of the Nepal Medical Association
|November 26, 2010
PubMed
Summary
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In this study of lymph node biopsies, tuberculosis was the most frequent diagnosis, particularly in neck lymph nodes. This highlights the importance of histopathological examination for diagnosing lymphadenopathy.

Area of Science:

  • Pathology
  • Oncology
  • Infectious Diseases

Background:

  • Lymphadenopathy is a frequent outpatient clinical finding with diverse potential causes.
  • Accurate diagnosis of lymphadenopathy is crucial for patient management.

Purpose of the Study:

  • To analyze the histopathological diagnoses of lymph node biopsies.
  • To investigate the relationship between diagnosis, age, sex, and lymph node site.

Main Methods:

  • Retrospective analysis of lymph node biopsies from August 2003 to 2007.
  • Histopathological examination of all submitted lymph nodes.

Main Results:

  • Tubercular lymphadenitis was the most common diagnosis (42%), followed by reactive lymphadenitis (23%) and metastatic deposits (10%).

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  • Neck lymph nodes were most frequently biopsied (44%), with tuberculosis being the predominant diagnosis in this site.
  • Males constituted 49% and females 51% of patients; the most common age group was 21-30 years.

    • Conclusions:

    • Histopathological examination of lymph node biopsies is essential for diagnosing the cause of lymphadenopathy.
    • Tuberculosis is the leading cause of lymphadenitis requiring biopsy, especially in the neck region.