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Responsiveness to exercise training in juvenile dermatomyositis: a twin case study
Clarissa Omori1, Danilo M L Prado, Bruno Gualano
1Pediatric Rheumatology Unit, Children's Institute, School of Medicine, University of Sao Paulo (Av, Dr, Arnaldo, 455 - Cerqueira César), Sao Paulo 01246-903, Brazil.
BMC Musculoskeletal Disorders
|November 26, 2010
Summary
Exercise training improved strength and aerobic conditioning in a child with juvenile dermatomyositis (JDM) without worsening disease activity. This study explored exercise benefits for JDM patients.
Area of Science:
- Pediatric Rheumatology
- Exercise Physiology
- Clinical Research
Background:
- Juvenile dermatomyositis (JDM) often causes exercise intolerance and muscle weakness.
- The impact of exercise training on JDM patients remains understudied.
Observation:
- A 7-year-old JDM patient and her healthy twin sister participated in a 16-week exercise program.
- Assessments included strength, balance, mobility, muscle function, aerobic capacity, and disease markers.
Findings:
- Both twins showed improvements, with comparable relative gains in strength and aerobic capacity.
- The JDM patient demonstrated enhanced ventilatory anaerobic threshold and functional tests.
- No significant changes in inflammation, muscle enzymes, or disease activity were observed.
Implications:
- This case study suggests that exercise training can be beneficial for children with JDM.
- Exercise may improve physical function without exacerbating disease activity in non-active JDM.
- Further research is warranted to establish exercise guidelines for JDM.
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