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Intrinsically disordered domains deviate significantly from random sequences in mammalian proteins

Shunsuke Teraguchi1, Ashwini Patil, Daron M Standley

  • 1Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. teraguch@ifrec.osaka-u.ac.jp

BMC Bioinformatics
|November 26, 2010
PubMed
Summary

Mammalian intrinsically disordered domains (IDDs) exhibit unique sequence patterns distinct from random sequences, suggesting biophysical constraints shape their evolution. These findings highlight specific sequence preferences within IDDs, particularly in immune response proteins.

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