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Updated: Jun 6, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

[Enterococci resistant to glycopeptides].

Vincent Cattoir¹, Roland Leclercq

¹Centre national de référence de la résistance aux antibiotiques, Laboratoire associé entérocoques, service de microbiologie, CHU de Caen, avenue Côte de Nacre, Caen, France.

Medecine Sciences : M/S

|November 26, 2010

Summary

This summary is machine-generated.

Multidrug-resistant Enterococcus faecium causes infections and is resistant to glycopeptide antibiotics. Hospital-adapted strains (CC17) are spreading, necessitating surveillance and control measures.

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Area of Science:

Microbiology
Infectious Diseases
Genetics

Context:

Enterococci cause significant community- and hospital-acquired infections.
Glycopeptide antibiotics (vancomycin, teicoplanin) target bacterial cell wall synthesis.
Enterococcus faecium exhibits increasing multidrug resistance, including to glycopeptides.

Purpose:

To investigate the mechanisms and spread of glycopeptide-resistant Enterococcus faecium.
To identify characteristics of hospital-adapted strains contributing to outbreaks.

Summary:

Glycopeptide resistance in Enterococcus faecium arises from acquiring genes that alter cell wall precursors.
Hospital outbreaks are linked to a specific hospital-adapted clonal complex (CC17) of E. faecium.
CC17 strains display high-level resistance to ampicillin and fluoroquinolones and possess virulence factors.

Impact:

Effective control of enterococcal outbreaks requires understanding resistance mechanisms and strain epidemiology.
Surveillance of spreading hospital-adapted clonal strains is crucial for infection control.
New therapeutic antibiotics are available, but strain monitoring remains essential.