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Updated: Jun 6, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
Published on: August 28, 2014
[Hyalomatrix PA(®) in skin substitutes. About 10 cases]
P Perrot1, V Dellière, A Brancati
1Service de chirurgie plastique et reconstructrice, centre des bruˆle´s, hoˆpital Jean-Monnet, CHU de Nantes, 30, boulevard Jean-Monnet, 44093 Nantes cedex 01, France. pierre.perrot@chu-nantes.fr
Abstract:
During the surgical treatment of burns and reconstructive surgery, we can use autografts, allografts, xenografts or dermal substitutes. Acellular dermal substitutes, implantable medical devices of class III are composed mostly of collagen but also, more recently, derivatives of hyaluronic acid (Hyalomatrix PA(®)). Their mechanism of action is based on revascularization and colonization by fibroblasts of the patient. They are then used to screen for delayed epidermal grafting (2-stage procedure for Integra(®), Matriderm(®) 2mm, Renoskin(®), Hyalomatrix PA(®)) or simultaneous (1-time procedure for IntegraSL(®), Matriderm(®) 1mm). We report 10 cases of clinical use of Hyalomatrix PA(®) in the service of burns and plastic surgery of Nantes.
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