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Automation of labelling of Lipiodol with high-activity generator-produced 188Re
Nicolas Lepareur1, Valérie Ardisson, Nicolas Noiret
1Service de Médecine Nucléaire, Centre Régional de Lutte Contre le Cancer Eugène Marquis, CS 44229, 35042 Rennes, France. n.lepareur@rennes.fnclcc.fr
Abstract:
This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52±2.3% and extraction yield was 98.56±1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68±9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol ((188)Re-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07±0.9%).
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