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Updated: Jun 6, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
[Changing patterns in the clinical, pathological features of Hodgkin lymphoma]
Zsófia Miltényi1, Zsófia Simon, Edit Páyer
1Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, III. Belgyógyászati Klinika Debrecen Móricz Zs. krt. 22. 4032. mil03@freemail.hu
Unlabelled:
Hodgkin lymphoma shows a well-known geographic pattern, but temporal changes have been found recently as well.
Patients And Methods:
The Authors analyzed 439 Hodgkin lymphoma patients' clinicopathological and treatment data. Patients were treated at our department from 1980 until the end of 2008.
Results:
The first period contained 117 patients, the second 147 and third 115 Hodgkin lymphoma patients. The mean age of the patients was 40.1, 35.9 and 36.8 years in order. The male/female ratio: 1.42, 1.45, 1.04 in order. The incidence of mixed cellularity histological subtype is decreasing; nodular sclerosis shows an increasing tendency. The number of early stage patients (59.12%) is beyond the advanced stage (40%) in the last decade. The 10-year overall survival data were progressing 44.1%, 70.6% and 90.5% (survival prognosis) in the last decade.
Conclusions:
Changes can be explained by the altered nature of Hodgkin lymphoma, the changes in socioeconomic status and the development of diagnostic and therapy methods.
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