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Related Concept Videos

Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria. In...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

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The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

The International Nucleotide Sequence Database Collaboration.

Guy Cochrane1, Ilene Karsch-Mizrachi, Yasukazu Nakamura

  • 1EMBL, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. cochrane@ebi.ac.uk

Nucleic Acids Research
|November 26, 2010
PubMed
Summary
This summary is machine-generated.

The International Nucleotide Sequence Database Collaboration (INSDC) provides public nucleotide sequence data. Recent advances in next-generation sequencing have significantly increased data volumes, impacting INSDC

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Area of Science:

  • Bioinformatics
  • Genomics
  • Data Science

Background:

  • The International Nucleotide Sequence Database Collaboration (INSDC) is a global effort to capture, preserve, and present public domain nucleotide sequences.
  • INSDC facilitates consistent data submission and exchange through standardized formats and conventions.
  • Established policies on data access and publisher relations position INSDC as a cornerstone of the global bioinformatics infrastructure.

Purpose of the Study:

  • To introduce the International Nucleotide Sequence Database Collaboration (INSDC).
  • To outline current data growth patterns within INSDC.
  • To discuss the strategic challenges posed by increasing sequence data volumes.

Main Methods:

  • The article reviews the operational framework and data management strategies of the INSDC.
  • Analysis of historical and recent data submission trends is presented.
  • The impact of technological advancements on data infrastructure is discussed.

Main Results:

  • INSDC databases serve as a critical resource for the scientific record and bioinformatics.
  • Next-generation sequencing technologies have led to a step-change in data volume growth.
  • The increasing scale of data presents strategic challenges for INSDC's future operations.

Conclusions:

  • The INSDC plays a vital role in global biological data sharing.
  • Adapting INSDC strategy to accommodate rapid data growth is essential.
  • Continued collaboration is key to managing the challenges of large-scale sequence data.