Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantifying Evidence for Competing Biomedical Hypotheses using Large Language Models and Bayesian Analysis.

bioRxiv : the preprint server for biology·2026

Same author

3'UTR regulation of axon translation and optic nerve regeneration.

Molecular neurodegeneration·2026

Same author

Harnessing the stem cell potential in the human hippocampus to limit cognitive aging.

PLoS biology·2026

Same author

Corrigendum to "Oculomics and AI: The eye as a biomarker for health span" [Asia-Pac J Ophthalmol 15 (1) (2026) 100282].

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)·2026

Same author

Vis-OCT Explorer: an open-source software for visible-light optical coherence tomography data processing.

Biomedical optics express·2026

Same author

Reply.

Ophthalmology science·2026

Same journal

Concurrence of Inherited Nuclear and Mitochondrial DNA Optic Neuropathies.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026

Same journal

Aspergillus-Infiltrated Optic Nerve Sheath Meningioma in Immunocompetent Host Mimicking Optic Neuritis.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026

Same journal

Progression of Vitreous Detachment Leading to Exacerbation of Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026

Same journal

Characterizing the Role of Ophthalmologists in the Care of Patients With Suspected Giant Cell Arteritis at an Academic Medical Center.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026

Same journal

Optic Disc Drusen Is Frequently Not Reported on Computed Tomography Scans Performed for Other Reasons.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026

Same journal

Dorsal Midbrain Syndrome Due to Complicated Posterior Reversible Encephalopathy Syndrome.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Minimally-invasive Technique for Injection into Rat Optic Nerve

Minimally-invasive Technique for Injection into Rat Optic Nerve

Published on: May 19, 2015

Four steps to optic nerve regeneration.

Darcie L Moore¹, Jeffrey L Goldberg

¹Institute of Cell Biology, ETH, Zurich, Switzerland.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society

|November 26, 2010

Summary

This summary is machine-generated.

Optic nerve regeneration is hindered by four key challenges. Overcoming these hurdles is crucial for restoring vision after injury or disease.

More Related Videos

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Published on: May 12, 2011

Related Experiment Videos

Last Updated: Jun 6, 2026

Minimally-invasive Technique for Injection into Rat Optic Nerve

Minimally-invasive Technique for Injection into Rat Optic Nerve

Published on: May 19, 2015

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Published on: May 12, 2011

Area of Science:

Neuroscience
Ophthalmology
Regenerative Medicine

Background:

Optic nerve injury or neurodegenerative diseases cause permanent vision loss due to the optic nerve's inability to regenerate.
Retinal ganglion cell (RGC) axons, which transmit visual information, do not regrow after injury, and RGCs often die, resulting in irreversible blindness.

Purpose of the Study:

To identify and outline the critical challenges impeding optic nerve regeneration.
To provide a framework for developing therapeutic strategies aimed at restoring vision.

Main Methods:

This study is a review and synthesis of current knowledge on optic nerve regeneration.
It analyzes the biological barriers and cellular mechanisms involved in RGC axon growth and survival.

Main Results:

Four primary obstacles to RGC axon regeneration and survival were identified: RGC survival, the inhibitory optic nerve environment, intrinsic axon growth capacity, and target reinnervation.
Addressing these hurdles is essential for successful visual recovery.

Conclusions:

Successful optic nerve regeneration requires a multi-faceted approach targeting RGC survival, overcoming inhibitory factors, enhancing intrinsic growth potential, and ensuring proper neural circuit reconstruction.
Further research into these areas is vital for developing effective treatments for vision loss.