Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

MALDI-TOF Mass Spectrometry

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...

Rapid Identification of Pathogens

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lower Allele Frequency of <i>TERT</i>-rs2242652 in Sub-Saharan African Populations Compared With American Populations and Hepatocellular Carcinoma Risk.

JCO global oncology·2026

Same author

Tumor patterns and cancer risk in carriers of TP53 exonic germline variants that alter mRNA splicing.

European journal of human genetics : EJHG·2026

Same author

The TP53 gene contains a diversity box that makes it more than a tumor suppressor.

Cell death and differentiation·2026

Same author

Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.

EBioMedicine·2025

Same author

Host transcriptional responses to gut microbiome variation arising from urbanism.

bioRxiv : the preprint server for biology·2025

Same author

Transfer Learning for Survival-based Clustering of Predictors with an Application to <i>TP53</i> Mutation Annotation.

bioRxiv : the preprint server for biology·2025

Same journal

Artificial intelligence-augmented robotic surgery in gynecologic oncology: intraoperative assistance and analytics.

Current opinion in oncology·2026

Same journal

Artificial intelligence in cervical cancer screening and triage: a role-stratified systematic review and bivariate meta-analysis.

Current opinion in oncology·2026

Same journal

Deep learning assisting the surgical management of gynecologic cancers.

Current opinion in oncology·2026

Same journal

Pain management in pancreatic cancer: time to change our strategy!

Current opinion in oncology·2026

Same journal

Systemic radionuclide treatments in gastro-entero-pancreatic neuroendocrine tumours.

Current opinion in oncology·2026

Same journal

5-Fluorouracil at seventy: still attractive but barely understood. A cautionary tale for drug development.

Current opinion in oncology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Proteomics beyond proteomics: toward clinical applications.

Amelie Plymoth¹, Pierre Hainaut

¹International Agency for Research on Cancer, Group of Molecular Carcinogenesis, Lyon, France. amelie.plymoth@ki.se

Current Opinion in Oncology

|November 26, 2010

Summary

This summary is machine-generated.

Proteomics shows promise for biomarker discovery in biomedical research. Advances in validation and standardization are improving the translation of proteomics biomarkers into clinical applications.

More Related Videos

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

Related Experiment Videos

Last Updated: Jun 6, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

Area of Science:

Biomedical Research
Life Sciences
Proteomics

Background:

Proteomics applications are growing across life sciences, particularly in biomedical research for biomarker discovery.
Advances in instrumentation, methodologies, software, and databases have driven proteomics development.
Despite progress, clinical applications of proteomics have advanced slower than anticipated.

Purpose of the Study:

Review key areas in proteomics development.
Discuss applications of proteomics in biomedical research.
Highlight challenges and progress in clinical proteomics.

Main Methods:

Review of current literature and advancements in proteomics.
Analysis of factors influencing the translational pipeline of proteomics biomarkers.
Examination of regulatory changes impacting clinical proteomics.

Main Results:

Difficulty in validation and standardization historically slowed biomarker translation.
Consortium efforts have largely overcome these challenges, enabling drug-specific biomarker discovery.
New FDA classifications, like 'in-vitro diagnostic multivariate index assays,' recognize complex protein pattern integration.

Conclusions:

Consortium efforts and infrastructure development are crucial for clinical proteomics advancement.
Standardization and validation are key to improving reproducibility, sensitivity, and specificity.
Continued collaboration within the proteomics community will drive future progress in clinical applications.