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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Characteristics and Functions of Blood01:26

Characteristics and Functions of Blood

Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Blood product transfusion: does location make a difference?

Tina L Palmieri1, Soman Sen, Katrina Falwell

  • 1Shriners Hospital for Children Northern California and University of California, Davis, CA 95817, USA.

Journal of Burn Care & Research : Official Publication of the American Burn Association
|November 26, 2010
PubMed
Summary
This summary is machine-generated.

In pediatric burn patients, increased use of fresh frozen plasma (FFP), platelets, and cryoprecipitate is linked to higher mortality. Transfusion strategies may need to differ between the operating room and intensive care unit (ICU).

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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Pediatric critical care medicine
  • Burn injury management
  • Transfusion medicine

Background:

  • Anemia in critically ill patients can arise from acute blood loss and chronic losses.
  • Early blood product administration may improve outcomes, but transfusions in critical illness are linked to increased mortality.
  • Major burn injuries in children present unique challenges for anemia management due to surgical blood loss and ICU losses.

Purpose of the Study:

  • To investigate the association between fresh frozen plasma (FFP), platelet, and cryoprecipitate administration and patient outcomes in pediatric major burn injuries.
  • To evaluate transfusion practices in relation to mortality in children with severe burns.

Main Methods:

  • Retrospective review of pediatric patients admitted with >20% Total Body Surface Area (TBSA) burns between 2006 and 2009.
  • Data collected included demographics, injury characteristics, surgical procedures, blood product transfusions (FFP, platelets, cryoprecipitate, packed red blood cells - PRBCs), and outcomes.
  • Statistical analysis compared transfusion volumes and ratios between survivors and nonsurvivors.

Main Results:

  • Nonsurvivors had significantly larger burn sizes compared to survivors.
  • Nonsurvivors received substantially more FFP, platelets, and cryoprecipitate than survivors, particularly in the ICU setting.
  • The FFP to PRBC transfusion ratio was higher in nonsurvivors (3:4) compared to survivors (1:4), indicating a different transfusion strategy.

Conclusions:

  • Increased transfusion of FFP, platelets, and cryoprecipitate in pediatric burn patients is associated with increased mortality.
  • The findings suggest that transfusion strategies may need to be differentiated based on the clinical context, such as acute hemorrhage in the operating room versus ongoing red cell loss in the ICU.
  • Further research into optimized blood product utilization in severe burn management is warranted.