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Published on: February 16, 2018
Chiral separation by enantioselective liquid-liquid extraction.
Boelo Schuur1, Bastiaan J V Verkuijl, Adriaan J Minnaard
1University of Groningen, Chemical Engineering Department, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Organic & Biomolecular Chemistry
|November 26, 2010
Summary
Enantioselective liquid-liquid extraction (ELLE) offers a valuable method for separating chiral compounds. This review details ELLE principles and advances, covering various chiral extractant classes for diverse chemical applications.
Area of Science:
- Chiral Separations
- Analytical Chemistry
- Chemical Engineering
Background:
- Enantioselective liquid-liquid extraction (ELLE) has been researched for over 50 years.
- A comprehensive review of ELLE has not been published in recent decades.
- ELLE is crucial for industries including pharmaceuticals, agrochemicals, and fine chemicals.
Purpose of the Study:
- To provide a comprehensive overview of enantioselective liquid-liquid extraction.
- To discuss the principles and recent advances in chiral resolution via ELLE.
- To review existing literature on ELLE systems, categorized by extractant type.
Main Methods:
- Review of scientific literature on enantioselective liquid-liquid extraction.
- Discussion of fundamental principles: host-guest chemistry, extraction, and phase transfer.
- Categorization of chiral extractants: crown ethers, metal complexes, tartrates, and others.
Main Results:
- Detailed explanation of ELLE principles and multistage processing.
- Systematic review of various chiral extractant classes used in ELLE.
- Identification of key developments and trends in the field over the past decades.
Conclusions:
- Enantioselective liquid-liquid extraction remains a vital technology for chiral separations.
- This review consolidates knowledge on ELLE principles and extractant systems.
- It serves as a reference for researchers and engineers in chiral chemistry and related fields.
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