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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Endpoints in pediatric pain studies.

Monique van Dijk1, Ilse Ceelie, Dick Tibboel

  • 1Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.

European Journal of Clinical Pharmacology
|November 26, 2010
PubMed
Summary

Measuring pain in young children presents challenges. This review examines current and novel pain assessment tools used as primary endpoints in pediatric analgesic drug studies.

Area of Science:

  • Pediatric Pain Management
  • Clinical Trial Endpoints
  • Pharmacology

Background:

  • Assessing pain intensity in preverbal children is significantly more challenging than in adults.
  • Standardized pain assessment tools are crucial for evaluating the efficacy of analgesic drugs in pediatric populations.
  • Existing endpoints in pediatric pain studies include pain intensity, time to analgesia, and adverse event monitoring.

Purpose of the Study:

  • To review current and emerging endpoints for pediatric pain assessment in clinical trials.
  • To highlight the importance of validated pain measures in pediatric analgesic drug studies.
  • To provide an overview of tools suitable for measuring pain in children, particularly those unable to self-report.

Main Methods:

  • Literature review of studies on pediatric pain assessment.

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  • Analysis of endpoints used in clinical trials for analgesic drugs in children.
  • Identification and categorization of current and novel pain measurement tools.

    • Main Results:

    • Pain intensity and time to first analgesia are commonly used primary endpoints.
    • Adverse effects and long-term outcomes are also critical considerations in pediatric studies.
    • Emerging endpoints may offer more objective or sensitive measures of pain in young children.

    Conclusions:

    • Effective pediatric pain assessment relies on appropriate and validated endpoints.
    • The selection of endpoints significantly impacts the interpretation of analgesic drug efficacy in children.
    • Continued research into novel pain assessment tools is essential for advancing pediatric pain management.