Related Experiment Videos
Rh haemolytic disease: continuing problem of management
D J Swinhoe1, D H Gilmore, M B McNay
1Queen Mother's Hospital, Glasgow, Department of Obstetrics and Gynaecology.
Archives of Disease in Childhood
|April 1, 1990
Summary
Severe Rh haemolytic disease management improved with fetal blood sampling and intrauterine transfusions. Early referral to specialist centers is crucial for better outcomes in Rh hemolytic disease cases.
Area of Science:
- Perinatology
- Hematology
Background:
- Severe Rh haemolytic disease poses significant risks to fetal survival.
- Traditional prognostic indicators for Rh haemolytic disease have shown limitations.
Purpose of the Study:
- To evaluate the effectiveness of fetal blood sampling and intrauterine transfusions in managing severe Rh haemolytic disease.
- To assess the accuracy of traditional prognostic indicators versus direct fetal assessments.
Main Methods:
- Study included 18 patients with severe Rh haemolytic disease.
- Fetal blood sampling and intrauterine transfusions were performed.
- Fetal packed cell volume was measured to assess hemolysis.
Main Results:
- Twelve babies (67%) survived, all delivered via lower segment caesarean section.
- Three intrauterine deaths, one stillbirth (Trisomy 21), and two neonatal deaths (prematurity) occurred.
- Fetal blood sampling and packed cell volume measurement were direct indicators of hemolysis, outperforming traditional methods.
Conclusions:
- Fetal blood sampling and intrauterine transfusion are vital in managing severe Rh haemolytic disease.
- The unpredictable progression of Rh haemolytic disease necessitates specialist center referral.
- Accurate assessment of hemolysis through fetal blood parameters is critical for improved outcomes.