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Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility

Da-Tian Bau1, Chao-Hsiang Chang, Ming-Hsui Tsai

  • 1Terry Fox Cancer Research Lab, China Medical University, Taichung, Taiwan. artbau1@yahoo.com.tw

The Laryngoscope
|November 26, 2010
PubMed
Abstract

Insights

Genetic variations in the ATM gene, specifically the rs189037 polymorphism, are linked to increased oral cancer risk. This finding may aid in early detection and prevention strategies for oral cancer.

Area of Science:

  • Genetics and Genomics
  • Cancer Research
  • Molecular Biology

Background:

  • The Ataxia-Telangiectasia Mutated (ATM) gene is crucial for maintaining genome stability.
  • ATM mutations are associated with various human cancers.
  • The role of ATM gene polymorphisms in oral carcinogenesis remains largely uninvestigated.

Purpose of the Study:

  • To investigate the association between ATM gene polymorphisms and susceptibility to oral cancer.
  • To explore the potential of ATM variants as biomarkers for oral cancer risk.

Main Methods:

  • A hospital-based case-control study involving 620 oral cancer patients and 620 healthy controls from Taiwan.
  • Genotyping of seven ATM single nucleotide polymorphisms (SNPs) using Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP).

Main Results:

  • A statistically significant association was found between the ATM rs189037 polymorphism and oral cancer risk (genotype P = 3.71E-6; allele P = 5.09E-6).
  • No significant differences were observed for the other six investigated ATM polymorphisms.
  • Synergistic interactions were noted between ATM genotyping and lifestyle factors like smoking, alcohol consumption, and betel quid chewing.

Conclusions:

  • The 'A' allele of the ATM rs189037 polymorphism is correlated with an increased susceptibility to oral cancer.
  • ATM rs189037 may serve as a valuable genetic marker for oral cancer prevention and early diagnosis.

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