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Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology

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Rabies virus strains circulating in Bhutan: implications for control.

Tenzin¹, S Wacharapluesadee, J Denduangboripant

¹Faculty of Veterinary Science, The University of Sydney, Camden, Australia.

Epidemiology and Infection

|November 27, 2010

Summary

Rabies virus (RABV) strains in Bhutanese animals were studied. Molecular epidemiology revealed these viruses are closely related to Indian strains, suggesting a common origin.

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Area of Science:

Veterinary Virology
Molecular Epidemiology
Genetics

Background:

Rabies virus (RABV) poses a significant threat to animal and public health globally.
Understanding the molecular epidemiology of RABV is crucial for effective control strategies.
Limited data exists on RABV strains circulating in Bhutanese animal populations.

Purpose of the Study:

To conduct a molecular epidemiological study of rabies virus (RABV) strains in Bhutan.
To investigate the potential origins and genetic relationships of these circulating RABV strains.
To compare Bhutanese RABV isolates with global strains.

Main Methods:

Twenty-three RABV isolates from dogs and domestic animals in Bhutan were collected.
Partial nucleoprotein (N) gene sequencing (395 bp) was performed for each isolate.
Phylogenetic analysis was used to determine the genetic relationships of Bhutanese RABV strains.

Main Results:

All Bhutanese RABV isolates analyzed were highly genetically similar.
Phylogenetic analysis indicated a close relationship between Bhutanese and Indian RABV strains.
The findings also showed a connection to South Asian Arctic-like-1 viruses.

Conclusions:

The rabies viruses circulating in southern Bhutan likely share a common ancestor.
The data strongly suggests an origin from Indian rabies virus strains.
This study provides critical insights into RABV transmission dynamics in the region.