Lowe's syndrome with Fanconi syndrome for ocular surgery: perioperative anesthetic considerations

Area of Science:

• Biochemistry
• Pediatrics
• Genetics

Background:

• Lowe's syndrome is a rare X-linked inherited metabolic disorder.
• It is characterized by congenital cataracts, intellectual disability, and renal tubulopathy.
• Fanconi's syndrome is a generalized proximal renal tubule dysfunction.

Observation:

• A case of a 4-month-old infant with Lowe's syndrome and Fanconi's syndrome is presented.
• The infant required bilateral congenital cataract surgery.
• Preoperative electrolyte imbalances were noted.

Findings:

• Electrolyte imbalances were corrected with potassium, calcium, magnesium, phosphate, and bicarbonate supplementation.
• Anesthesia was administered successfully using appropriate agents and monitoring.
• The perioperative period was managed with careful attention to fluid and electrolyte balance.

Implications:

• This case highlights the importance of thorough preoperative evaluation and optimization in patients with Lowe's syndrome.
• Careful anesthetic management and meticulous fluid and electrolyte monitoring are essential for successful surgical outcomes.
• Early diagnosis and management can improve the quality of life for affected individuals.