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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Post infectious bronchiolitis obliterans in children

Gilberto B Fischer1, Edgar E Sarria, Rita Mattiello

  • 1Department of Paediatrics, Universidade Federal de Ciencias da Saude, Porto Alegre, Brazil. gbuenof@terra.com.br

Paediatric Respiratory Reviews
|November 27, 2010
PubMed

Insights

Bronchiolitis Obliterans (BO) is a rare obstructive lung disease. This review focuses on the post-infectious type in children, its epidemiology, diagnosis, and treatment.

Area of Science:

  • Pulmonology
  • Pediatric Respiratory Medicine

Background:

  • Bronchiolitis Obliterans (BO) is a rare, chronic obstructive lung disease affecting the small airways.
  • In children, it commonly presents as post-infectious BO following severe viral infections.
  • Post-transplant BO is increasing due to organ and bone-marrow transplants.

Purpose of the Study:

  • To review current evidence on post-infectious Bronchiolitis Obliterans in children.
  • To discuss epidemiology, diagnosis, treatment, and prognosis.
  • To highlight areas of controversy for future research.

Main Methods:

  • Literature review of up-to-date evidence.
  • Synthesis of information on epidemiology, diagnosis, treatment, and prognosis.
  • Identification of controversial aspects and future research directions.

Main Results:

  • Post-infectious BO in children is linked to early-life viral infections.
  • Post-transplant BO is progressive, unlike the generally non-progressive post-infectious form.
  • Both forms share pathological pathways leading to bronchiolar obliteration.

Conclusions:

  • Post-infectious Bronchiolitis Obliterans requires further investigation regarding its long-term course and management.
  • Understanding shared pathways may offer therapeutic insights.
  • Further research is needed to address current controversies and improve patient outcomes.

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