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Related Experiment Video

Updated: Jun 6, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Post infectious bronchiolitis obliterans in children.

Gilberto B Fischer¹, Edgar E Sarria, Rita Mattiello

¹Department of Paediatrics, Universidade Federal de Ciencias da Saude, Porto Alegre, Brazil. gbuenof@terra.com.br

Paediatric Respiratory Reviews

|November 27, 2010

Summary

Bronchiolitis Obliterans (BO) is a rare obstructive lung disease. This review focuses on the post-infectious type in children, its epidemiology, diagnosis, and treatment.

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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Area of Science:

Pulmonology
Pediatric Respiratory Medicine

Background:

Bronchiolitis Obliterans (BO) is a rare, chronic obstructive lung disease affecting the small airways.
In children, it commonly presents as post-infectious BO following severe viral infections.
Post-transplant BO is increasing due to organ and bone-marrow transplants.

Purpose of the Study:

To review current evidence on post-infectious Bronchiolitis Obliterans in children.
To discuss epidemiology, diagnosis, treatment, and prognosis.
To highlight areas of controversy for future research.

Main Methods:

Literature review of up-to-date evidence.
Synthesis of information on epidemiology, diagnosis, treatment, and prognosis.
Identification of controversial aspects and future research directions.

Main Results:

Post-infectious BO in children is linked to early-life viral infections.
Post-transplant BO is progressive, unlike the generally non-progressive post-infectious form.
Both forms share pathological pathways leading to bronchiolar obliteration.

Conclusions:

Post-infectious Bronchiolitis Obliterans requires further investigation regarding its long-term course and management.
Understanding shared pathways may offer therapeutic insights.
Further research is needed to address current controversies and improve patient outcomes.