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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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Related Experiment Video

Updated: Jun 6, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Fat-induced inflammation unchecked.

Olivia Osborn1, Dorothy D Sears, Jerrold M Olefsky

  • 1Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA.

Cell Metabolism
|November 27, 2010
PubMed
Summary
This summary is machine-generated.

Dietary saturated fat causes health issues. Angiopoietin-like protein 4 (Angptl4) protects macrophages from saturated fatty acid inflammation by inhibiting lipoprotein lipase (LPL) in lymph nodes.

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Last Updated: Jun 6, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

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Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
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Isolation of Adipose Tissue Immune Cells
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Area of Science:

  • Metabolic research
  • Immunology
  • Cardiovascular health

Background:

  • High intake of dietary saturated fat poses significant health risks.
  • Inflammation in macrophages is a key factor in diet-induced metabolic dysfunction.

Discussion:

  • Angiopoietin-like protein 4 (Angptl4) plays a crucial role in regulating lipid metabolism and inflammation.
  • Lipoprotein lipase (LPL) activity in mesenteric lymph nodes is identified as a target for Angptl4's protective effects.

Key Insights:

  • Angptl4 inhibits LPL activity within mesenteric lymph nodes.
  • This inhibition by Angptl4 shields macrophages from inflammation triggered by dietary saturated fatty acids (SFAs).

Outlook:

  • Understanding Angptl4's mechanism offers potential therapeutic targets for managing SFA-induced inflammation.
  • Further research could explore Angptl4 modulation for preventing or treating metabolic diseases linked to dietary fat intake.