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Published on: November 20, 2015
Erythropoietin in neonatal brain protection: the past, the present and the future
Abdullah Kumral1, Funda Tüzün, Meryem Gülfer Oner
1Department of Pediatrics, Division of Neonatology, School of Medicine, Dokuz Eylul University, Izmir, Turkey. abdullah.kumral@deu.edu.tr
Abstract:
Over the last decade, neuroprotective effects of erythropoietin (Epo) and its underlying mechanisms in terms of signal transduction pathways have been defined and there is a growing interest in the potential therapeutic use of Epo for neuroprotection. Several mechanisms by which Epo provides neuroprotection are recognized. In this review, we focused on the neuroprotective mechanisms of Epo and provide a short overview on both experimental and clinical studies, testing Epo as a neuroprotective agent in the neonatal brain injury, and the safety concerns with the clinical use of Epo treatment in neonates.
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