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MIPS: curated databases and comprehensive secondary data resources in 2010.

H Werner Mewes¹, Andreas Ruepp, Fabian Theis

¹Institute for Bioinformatics and Systems Biology, MIPS, Helmholtz Center F Health and Environment, Ingolstädter Landstr 1, D-85764 Neuherberg, Germany. w.mewes@helmholtz-muenchen.de

Nucleic Acids Research

|November 27, 2010

Summary

The Munich Information Center for Protein Sequences (MIPS) provides curated biological data, including model genomes and protein sequences. Their resources offer comprehensive annotation and tools for functional genomics and comparative plant research.

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Area of Science:

Bioinformatics
Genomics
Proteomics

Background:

The Munich Information Center for Protein Sequences (MIPS) has extensive experience in curating biological data.
MIPS utilizes both manual curation for high-relevance datasets and automated annotation for high-throughput data.

Purpose of the Study:

To present the diverse, annotated biological data resources and tools developed and maintained by MIPS.
To highlight MIPS's contributions to genomics, proteomics, and functional genomics research.

Main Methods:

Manual curation of selected datasets (e.g., model genomes).
Automated annotation pipelines for large-scale biological data.
Development of specialized databases and literature-mining tools.

Main Results:

Maintenance of high-quality resources like Saccharomyces cerevisiae, Neurospora crassa, and Arabidopsis thaliana genome databases.
Development of PhenomiR, MIPS PlantsDB, SIMAP, PEDANT, PPLIPS, CCancer, and EXCERBT.
Annotation of 38,000,000 protein sequences with homology relationships.

Conclusions:

MIPS offers a comprehensive suite of integrated resources for biological data analysis.
These resources facilitate research in comparative genomics, proteomics, and disease-related studies.
All MIPS databases and project details are accessible via their WWW server.