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Updated: Jun 6, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

[Action of type III IFNs and their roles in immune responses]

Krzysztof Domagalski1, Andrzej Tretyn, Małgorzata Pawłowska

  • 1Zakład Biotechnologii, Instytut Biologii Ogólnej i Molekularnej, Uniwersytet Mikołaja Kopernika w Toruniu, Toruń. kdkrydom@gmail.com

Postepy Higieny I Medycyny Doswiadczalnej (Online)
|November 27, 2010
PubMed

Type III interferons, also known as IFN-lambda or IL-28/29, are a recently discovered family of IFNs related to both the type I IFNs and interleukin-10 family members. Interferon-lambda is functionally an interferon but structurally it is related to the interleukin-10 family. These novel cytokines are directly induced during viral infection like type-I interferons and signal through a similar JAK-STAT signaling pathway as type I IFN to activate the transcription of a similar set of IFN-stimulated genes (ISG) but use a separate receptor complex. ISG product induced by the type III family of IFNs are associated with immunomodulatory ability, antiviral activity and other effects. The antiviral and immunomodulatory effects of type III interferons make them interesting therapeutics for clinical use. In this review, we summarize the current state of knowledge about the biology of IFN-lambdas and their roles in immune responses via immunomodulatory and antiviral activity.

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