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State of the Art Cranial Ultrasound Imaging in Neonates
Published on: February 2, 2015
Hemimegalencephaly: 2D, 3D Ultrasound and MRI Correlation
X C Romero1, F S Molina, E Pastor
1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Fetal Diagnosis and Therapy
|November 27, 2010
Summary
Early diagnosis of hemimegalencephaly (HMC), a brain overgrowth disorder, is possible with ultrasound. Advanced imaging aids in precise diagnosis and parental counseling for fetal HMC.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Imaging
Background:
- Hemimegalencephaly (HMC) involves enlarged, dysplastic cerebral hemisphere overgrowth.
- Normal brain development includes hemisphere formation and cortical organization (12-20 weeks gestation).
Observation:
- A 22-week fetus presented with macrocephaly due to HMC.
- Utilized 2D and 3D ultrasound for diagnosis.
- Magnetic resonance imaging (MRI) was employed for detailed assessment.
Findings:
- Early prenatal diagnosis of HMC is feasible via anomaly scans.
- Correlating ultrasound findings with MRI enhances diagnostic accuracy.
- Identified neuronal migration anomalies through advanced imaging.
Implications:
- Prenatal diagnosis of HMC can be achieved during routine anomaly scans.
- Multimodal imaging (ultrasound and MRI) is crucial for precise diagnosis.
- Accurate diagnosis facilitates informed genetic counseling for affected families.
