Related Experiment Video
Updated: Jun 6, 2026
06:03
Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
Published on: July 21, 2023
[Long-lasting low back pain and MRI changes in the intervertebral discs]
Ellina Iordanova1, Cecilie Røe, Anne Keller
1Avdeling for fysikalsk medisin og rehabilitering, Oslo universitetssykehus, Ullevål, Norway.
Summary
Genetic factors may influence persistent low back pain. Research links Modic changes on MRI to pain, with genetics potentially playing a role in inflammation and nerve growth, aiding future diagnostics and treatments.
Area of Science:
- Orthopedics
- Genetics
- Radiology
Context:
- Low back pain (LBP) is a common condition, often temporary, but can become chronic and debilitating for some.
- Identifying causal factors for persistent LBP is crucial for effective treatment development.
Purpose:
- To review recent research on MRI findings, specifically Modic changes, and genetic factors associated with the development of long-lasting low back pain.
- To explore the link between Modic changes, inflammation, nerve ingrowth, and potential genetic predispositions.
Summary:
- Low back pain frequently originates from spinal structures like intervertebral discs and facet joints.
- Modic changes, visible on MRI, are associated with LBP and may involve inflammation and nociceptive nerve fiber growth.
- Genetic factors may influence the extent of these changes and the development of chronic pain.
Impact:
- Advances in understanding genetic contributions and Modic changes can lead to improved diagnostic tools for chronic LBP.
- This knowledge may facilitate the development of more targeted and personalized treatment strategies for patients with persistent low back pain.
Related Concept Videos
01:23Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
01:27Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
01:29Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...